(TECHNOLOGY)

PLATFORM

PIN PLATFORM PROVIDES A UNIQUE OPPORTUNITY TO TARGET COMPLEX PATHOLOGIES

EFFECTOR CELLS

TARGETING LIGANDS

FOR ANY GIVEN TARGET AND INDICATION

(NK CELLS)

(MACROPHAGES)

(OTHER CELLS)

(ANTIBODIES)

(LIGANDS)

(HEMATOLOGY)

(SOLID TUMOR)

(AUTOIMMUNE DESEASES)

(TECHNOLOGY)

OVERVIEW

ARMED EFFECTORS CELLS

PATENTED ENGINEERING OF MABS AND FC-BASED LIGANDS ENABLING FORMULATION OF ARMED EFFECTORS CELLS FOR STABLE AND PERSISTENT POTENCY IN AN OFF-THE-SHELF FORMAT.

EFFECTOR CELL

ANY EFFECTOR CELLS WITH A NATURAL OR ENGINEERED CD16 RECEPTOR (NK, MACROPHAGES, ETC.)

FOR EACH EFFECTOR CELL TYPE, ONE CELL PRODUCT CAN CAUSED WITH MANY DIFFERENT LIGANDS

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TARGETING LIGAND

MONOCLONAL ANTIBODY OR FC CONSTRUCT

  • PATENTED ENGINEERING OF FC PART TO PERMANENTLY ARM CELLS PRIOR TO ADMINISTRATION
  • CAN BE APPLIED ACROSS FULL LIBRARY OF KNOWN MABS, AS WELL AS NEW ONES AND FC-BASED LIGANDS (PEPTIDES, ANTIGENS, RECEPTORS)
  • SPECIFIC ANTIGENS EXPRESSED BY TUMOR CELLS

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DRUG PRODUCT

  • MANUFACTURING – SELF-ASSEMBLY UPON MIXING OF CELLS AND LIGAND MOLECULES
  • REGULATORY – same core drug substance characteristics for multiple unique products
  • MODULARITY – rapid formulation of cell therapy products for identified targets having an available ligand.